Distinct EMT programs control normal mammary stem cells and tumour-initiating cells

Xin Ye (), Wai Leong Tam, Tsukasa Shibue, Yasemin Kaygusuz, Ferenc Reinhardt, Elinor Ng Eaton and Robert A. Weinberg ()
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Xin Ye: Whitehead Institute for Biomedical Research
Wai Leong Tam: Whitehead Institute for Biomedical Research
Tsukasa Shibue: Whitehead Institute for Biomedical Research
Yasemin Kaygusuz: Whitehead Institute for Biomedical Research
Ferenc Reinhardt: Whitehead Institute for Biomedical Research
Elinor Ng Eaton: Whitehead Institute for Biomedical Research
Robert A. Weinberg: Whitehead Institute for Biomedical Research

Nature, 2015, vol. 525, issue 7568, 256-260

Abstract: This study finds that the epithelial-to-mesenchymal (EMT) transition program, which is common to both mammary gland reconstituting stem cells and mammary tumour-initiating cells, is differentially regulated by two distinct EMT factors, Slug and Snail; the findings illustrate that although they appear similar, normal tissue stem cells and tumour-initiating cells are controlled by distinct regulatory processes.

Date: 2015
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DOI: 10.1038/nature14897

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