Single-cell messenger RNA sequencing reveals rare intestinal cell types

Dominic Grün, Anna Lyubimova, Lennart Kester, Kay Wiebrands, Onur Basak, Nobuo Sasaki, Hans Clevers and Alexander van Oudenaarden ()
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Dominic Grün: Hubrecht Institute-KNAW (Royal Netherlands Academy of Arts and Sciences)
Anna Lyubimova: Hubrecht Institute-KNAW (Royal Netherlands Academy of Arts and Sciences)
Lennart Kester: Hubrecht Institute-KNAW (Royal Netherlands Academy of Arts and Sciences)
Kay Wiebrands: Hubrecht Institute-KNAW (Royal Netherlands Academy of Arts and Sciences)
Onur Basak: Hubrecht Institute-KNAW (Royal Netherlands Academy of Arts and Sciences)
Nobuo Sasaki: Hubrecht Institute-KNAW (Royal Netherlands Academy of Arts and Sciences)
Hans Clevers: Hubrecht Institute-KNAW (Royal Netherlands Academy of Arts and Sciences)
Alexander van Oudenaarden: Hubrecht Institute-KNAW (Royal Netherlands Academy of Arts and Sciences)

Nature, 2015, vol. 525, issue 7568, 251-255

Abstract: An algorithm that allows rare cell type identification in a complex population of single cells, based on single-cell mRNA-sequencing, is applied to mouse intestinal cells, revealing novel subtypes of enteroendocrine cells and showing that the Lgr5-expressing population consists of a homogenous stem cell population with a few rare secretory cells, including Paneth cells.

Date: 2015
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DOI: 10.1038/nature14966

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