A spatial model predicts that dispersal and cell turnover limit intratumour heterogeneity

Bartlomiej Waclaw, Ivana Bozic, Meredith E. Pittman, Ralph H. Hruban, Bert Vogelstein and Martin A. Nowak ()
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Bartlomiej Waclaw: School of Physics and Astronomy, University of Edinburgh, JCMB
Ivana Bozic: Program for Evolutionary Dynamics, Harvard University
Meredith E. Pittman: The Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins University School of Medicine
Ralph H. Hruban: The Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins University School of Medicine
Bert Vogelstein: The Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins University School of Medicine
Martin A. Nowak: Program for Evolutionary Dynamics, Harvard University

Nature, 2015, vol. 525, issue 7568, 261-264

Abstract: A new model of tumour evolution is presented to explain how short-range migration and cell turnover within the tumour can provide the basic environment of rapid cell mixing, allowing even a small selective advantage to dominate the mass within relevant time frames.

Date: 2015
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DOI: 10.1038/nature14971

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