Evidence for human transmission of amyloid-β pathology and cerebral amyloid angiopathy

Zane Jaunmuktane, Simon Mead, Matthew Ellis, Jonathan D. F. Wadsworth, Andrew J. Nicoll, Joanna Kenny, Francesca Launchbury, Jacqueline Linehan, Angela Richard-Loendt, A. Sarah Walker, Peter Rudge, John Collinge () and Sebastian Brandner ()
Additional contact information
Zane Jaunmuktane: The National Hospital for Neurology and Neurosurgery
Simon Mead: Medical Research Council Prion Unit
Matthew Ellis: UCL Institute of Neurology
Jonathan D. F. Wadsworth: Medical Research Council Prion Unit
Andrew J. Nicoll: Medical Research Council Prion Unit
Joanna Kenny: Medical Research Council Prion Unit
Francesca Launchbury: UCL Institute of Neurology
Jacqueline Linehan: Medical Research Council Prion Unit
Angela Richard-Loendt: UCL Institute of Neurology
A. Sarah Walker: MRC Clinical Trials Unit at University College London
Peter Rudge: Medical Research Council Prion Unit
John Collinge: Medical Research Council Prion Unit
Sebastian Brandner: The National Hospital for Neurology and Neurosurgery

Nature, 2015, vol. 525, issue 7568, 247-250

Abstract: Treatment of children with human cadaver-derived growth hormone (c-hGH) contaminated with prions resulted in transmission of Creutzfeldt–Jakob disease (CJD); unexpectedly, in an autopsy study of eight such iCJD patients, the authors found amyloid-β deposition in the grey matter typical of that seen in Alzheimer's disease and amyloid-β in the blood vessel walls characteristic of cerebral amyloid angiopathy, consistent with iatrogenic transmission of amyloid-β pathology in addition to CJD and suggests that healthy c-hGH-exposed individuals may also be at risk of Alzheimer's disease and cerebral amyloid angiopathy.

Date: 2015
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DOI: 10.1038/nature15369

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