Replisome speed determines the efficiency of the Tus−Ter replication termination barrier

Mohamed M. Elshenawy, Slobodan Jergic, Zhi-Qiang Xu, Mohamed A. Sobhy, Masateru Takahashi, Aaron J. Oakley, Nicholas E. Dixon () and Samir M. Hamdan ()
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Mohamed M. Elshenawy: King Abdullah University of Science and Technology
Slobodan Jergic: Centre for Medical & Molecular Bioscience, Illawarra Health & Medical Research Institute and University of Wollongong
Zhi-Qiang Xu: Centre for Medical & Molecular Bioscience, Illawarra Health & Medical Research Institute and University of Wollongong
Mohamed A. Sobhy: King Abdullah University of Science and Technology
Masateru Takahashi: King Abdullah University of Science and Technology
Aaron J. Oakley: Centre for Medical & Molecular Bioscience, Illawarra Health & Medical Research Institute and University of Wollongong
Nicholas E. Dixon: Centre for Medical & Molecular Bioscience, Illawarra Health & Medical Research Institute and University of Wollongong
Samir M. Hamdan: King Abdullah University of Science and Technology

Nature, 2015, vol. 525, issue 7569, 394-398

Abstract: The Tus–Ter termination site of Escherichia coli is not completely efficient in stopping DNA replication, with about half of replisomes bypassing this blockade; here the speed of the replication machinery is shown to determine the outcome of the encounter between the replisome and Tus–Ter.

Date: 2015
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DOI: 10.1038/nature14866

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