Integrator mediates the biogenesis of enhancer RNAs

Fan Lai, Alessandro Gardini, Anda Zhang and Ramin Shiekhattar ()
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Fan Lai: University of Miami Miller School of Medicine, Sylvester Comprehensive Cancer Center, Biomedical Research Building
Alessandro Gardini: University of Miami Miller School of Medicine, Sylvester Comprehensive Cancer Center, Biomedical Research Building
Anda Zhang: University of Miami Miller School of Medicine, Sylvester Comprehensive Cancer Center, Biomedical Research Building
Ramin Shiekhattar: University of Miami Miller School of Medicine, Sylvester Comprehensive Cancer Center, Biomedical Research Building

Nature, 2015, vol. 525, issue 7569, 399-403

Abstract: This study demonstrates a role for the Integrator complex in the stimulus-dependent induction of eRNAs and their 3′ processing; together with previously known roles of Integrator in transcription elongation and RNA processing, these results indicate that Integrator has broad functions in the regulation of eukaryotic gene expression.

Date: 2015
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DOI: 10.1038/nature14906

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