The spliceosome is a therapeutic vulnerability in MYC-driven cancer

Tiffany Y.-T. Hsu, Lukas M. Simon, Nicholas J. Neill, Richard Marcotte, Azin Sayad, Christopher S. Bland, Gloria V. Echeverria, Tingting Sun, Sarah J. Kurley, Siddhartha Tyagi, Kristen L. Karlin, Rocio Dominguez-Vidaña, Jessica D. Hartman, Alexander Renwick, Kathleen Scorsone, Ronald J. Bernardi, Samuel O. Skinner, Antrix Jain, Mayra Orellana, Chandraiah Lagisetti, Ido Golding, Sung Y. Jung, Joel R. Neilson, Xiang H.-F. Zhang, Thomas A. Cooper, Thomas R. Webb, Benjamin G. Neel, Chad A. Shaw and Thomas F. Westbrook ()
Additional contact information
Tiffany Y.-T. Hsu: Baylor College of Medicine
Lukas M. Simon: Baylor College of Medicine
Nicholas J. Neill: Baylor College of Medicine
Richard Marcotte: Princess Margaret Cancer Centre, University Health Network
Azin Sayad: Princess Margaret Cancer Centre, University Health Network
Christopher S. Bland: Baylor College of Medicine
Gloria V. Echeverria: Baylor College of Medicine
Tingting Sun: Baylor College of Medicine
Sarah J. Kurley: Baylor College of Medicine
Siddhartha Tyagi: Baylor College of Medicine
Kristen L. Karlin: Baylor College of Medicine
Rocio Dominguez-Vidaña: Baylor College of Medicine
Jessica D. Hartman: Baylor College of Medicine
Alexander Renwick: Baylor College of Medicine
Kathleen Scorsone: Baylor College of Medicine
Ronald J. Bernardi: Baylor College of Medicine
Samuel O. Skinner: Baylor College of Medicine
Antrix Jain: Baylor College of Medicine
Mayra Orellana: Baylor College of Medicine
Chandraiah Lagisetti: Center for Chemical Biology, SRI International
Ido Golding: Baylor College of Medicine
Sung Y. Jung: Baylor College of Medicine
Joel R. Neilson: Baylor College of Medicine
Xiang H.-F. Zhang: The Lester and Sue Smith Breast Center, Baylor College of Medicine
Thomas A. Cooper: Baylor College of Medicine
Thomas R. Webb: Center for Chemical Biology, SRI International
Benjamin G. Neel: Princess Margaret Cancer Centre, University Health Network
Chad A. Shaw: Baylor College of Medicine
Thomas F. Westbrook: Baylor College of Medicine

Nature, 2015, vol. 525, issue 7569, 384-388

Abstract: Splicing factors such as BUD31 are identified in a synthetic-lethal screen with cells overexpressing the transcription factor MYC; oncogenic MYC leads to an increase in pre-mRNA synthesis, and spliceosome inhibition impairs the growth and tumorigenicity of MYC-dependent breast cancers, suggesting that spliceosome components may be potential therapeutic targets for MYC-driven cancers.

Date: 2015
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DOI: 10.1038/nature14985

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