Tet2 is required to resolve inflammation by recruiting Hdac2 to specifically repress IL-6

Qian Zhang, Kai Zhao, Qicong Shen, Yanmei Han, Yan Gu, Xia Li, Dezhi Zhao, Yiqi Liu, Chunmei Wang, Xiang Zhang, Xiaoping Su, Juan Liu, Wei Ge, Ross L. Levine, Nan Li and Xuetao Cao ()
Additional contact information
Qian Zhang: Institute of Basic Medical Sciences, Peking Union Medical College, Chinese Academy of Medical Sciences
Kai Zhao: Institute of Basic Medical Sciences, Peking Union Medical College, Chinese Academy of Medical Sciences
Qicong Shen: National Key Laboratory of Medical Immunology & Institute of Immunology, Second Military Medical University
Yanmei Han: National Key Laboratory of Medical Immunology & Institute of Immunology, Second Military Medical University
Yan Gu: National Key Laboratory of Medical Immunology & Institute of Immunology, Second Military Medical University
Xia Li: Institute of Basic Medical Sciences, Peking Union Medical College, Chinese Academy of Medical Sciences
Dezhi Zhao: Institute of Basic Medical Sciences, Peking Union Medical College, Chinese Academy of Medical Sciences
Yiqi Liu: National Key Laboratory of Medical Immunology & Institute of Immunology, Second Military Medical University
Chunmei Wang: Institute of Basic Medical Sciences, Peking Union Medical College, Chinese Academy of Medical Sciences
Xiang Zhang: National Key Laboratory of Medical Immunology & Institute of Immunology, Second Military Medical University
Xiaoping Su: National Key Laboratory of Medical Immunology & Institute of Immunology, Second Military Medical University
Juan Liu: National Key Laboratory of Medical Immunology & Institute of Immunology, Second Military Medical University
Wei Ge: Institute of Basic Medical Sciences, Peking Union Medical College, Chinese Academy of Medical Sciences
Ross L. Levine: Human Oncology and Pathogenesis Program and Leukemia Service, Memorial Sloan-Kettering Cancer
Nan Li: National Key Laboratory of Medical Immunology & Institute of Immunology, Second Military Medical University
Xuetao Cao: Institute of Basic Medical Sciences, Peking Union Medical College, Chinese Academy of Medical Sciences

Nature, 2015, vol. 525, issue 7569, 389-393

Abstract: The Tet2 enzyme, which catalyses de novo hydroxymethylation of DNA, is shown here to act as a transcriptional repressor by recruiting the histone deacetylase Hdac2 to the Il6 promoter in the course of resolution of the LPS-induced inflammatory response.

Date: 2015
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DOI: 10.1038/nature15252

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