Cell-fate determination by ubiquitin-dependent regulation of translation

Achim Werner, Shintaro Iwasaki, Colleen A. McGourty, Sofia Medina-Ruiz, Nia Teerikorpi, Indro Fedrigo, Nicholas T. Ingolia and Michael Rape ()
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Achim Werner: Howard Hughes Medical Institute, University of California
Shintaro Iwasaki: University of California
Colleen A. McGourty: University of California
Sofia Medina-Ruiz: University of California
Nia Teerikorpi: Howard Hughes Medical Institute, University of California
Indro Fedrigo: University of California
Nicholas T. Ingolia: University of California
Michael Rape: Howard Hughes Medical Institute, University of California

Nature, 2015, vol. 525, issue 7570, 523-527

Abstract: This study shows that a vertebrate-specific ubiquitin ligase modulates neural crest specification in Xenopus development and human embryonic stem-cell differentiation; a proteomics approach reveals that the CUL3KBTBD8 ligase modulates translation by targeting the modulators of ribosomes production NOLC1 and its paralogue TCOF1, which is mutated in a neural-crest-associated syndrome.

Date: 2015
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DOI: 10.1038/nature14978

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