Crystal structures of a double-barrelled fluoride ion channel

Randy B. Stockbridge, Ludmila Kolmakova-Partensky, Tania Shane, Akiko Koide, Shohei Koide, Christopher Miller and Simon Newstead ()
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Randy B. Stockbridge: Howard Hughes Medical Institute, Brandeis University
Ludmila Kolmakova-Partensky: Howard Hughes Medical Institute, Brandeis University
Tania Shane: Howard Hughes Medical Institute, Brandeis University
Akiko Koide: University of Chicago
Shohei Koide: University of Chicago
Christopher Miller: Howard Hughes Medical Institute, Brandeis University
Simon Newstead: University of Oxford

Nature, 2015, vol. 525, issue 7570, 548-551

Abstract: Microorganisms can export toxic fluoride ions through highly selective channels of the Fluc family; here, the crystal structures of two bacterial Fluc homologues are presented, revealing that selectivity for small F− ions may arise from the proteins’ narrow pores and unusual anion coordination.

Date: 2015
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DOI: 10.1038/nature14981

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