Neutrophil ageing is regulated by the microbiome

Dachuan Zhang, Grace Chen, Deepa Manwani, Arthur Mortha, Chunliang Xu, Jeremiah J. Faith, Robert D. Burk, Yuya Kunisaki, Jung-Eun Jang, Christoph Scheiermann, Miriam Merad and Paul S. Frenette ()
Additional contact information
Dachuan Zhang: Ruth L. and David S. Gottesman Institute for Stem Cell and Regenerative Medicine Research, Albert Einstein College of Medicine
Grace Chen: Ruth L. and David S. Gottesman Institute for Stem Cell and Regenerative Medicine Research, Albert Einstein College of Medicine
Deepa Manwani: Albert Einstein College of Medicine
Arthur Mortha: Mount Sinai School of Medicine
Chunliang Xu: Ruth L. and David S. Gottesman Institute for Stem Cell and Regenerative Medicine Research, Albert Einstein College of Medicine
Jeremiah J. Faith: The Immunology Institute, Mount Sinai School of Medicine
Robert D. Burk: Albert Einstein College of Medicine
Yuya Kunisaki: Ruth L. and David S. Gottesman Institute for Stem Cell and Regenerative Medicine Research, Albert Einstein College of Medicine
Jung-Eun Jang: Ruth L. and David S. Gottesman Institute for Stem Cell and Regenerative Medicine Research, Albert Einstein College of Medicine
Christoph Scheiermann: Ruth L. and David S. Gottesman Institute for Stem Cell and Regenerative Medicine Research, Albert Einstein College of Medicine
Miriam Merad: Mount Sinai School of Medicine
Paul S. Frenette: Ruth L. and David S. Gottesman Institute for Stem Cell and Regenerative Medicine Research, Albert Einstein College of Medicine

Nature, 2015, vol. 525, issue 7570, 528-532

Abstract: Neutrophil ageing, which encourages inflammation and vaso-occlusion in a mouse model of sickle-cell disease, is shown to depend on the intestinal microbiota and activation of the TLR/Myd88 signalling pathways.

Date: 2015
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DOI: 10.1038/nature15367

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