Epicardial FSTL1 reconstitution regenerates the adult mammalian heart

Ke Wei, Vahid Serpooshan, Cecilia Hurtado, Marta Diez-Cuñado, Mingming Zhao, Sonomi Maruyama, Wenhong Zhu, Giovanni Fajardo, Michela Noseda, Kazuto Nakamura, Xueying Tian, Qiaozhen Liu, Andrew Wang, Yuka Matsuura, Paul Bushway, Wenqing Cai, Alex Savchenko, Morteza Mahmoudi, Michael D. Schneider, Maurice J. B. van den Hoff, Manish J. Butte, Phillip C. Yang, Kenneth Walsh, Bin Zhou, Daniel Bernstein, Mark Mercola and Pilar Ruiz-Lozano ()
Additional contact information
Ke Wei: University of California, San Diego
Vahid Serpooshan: Stanford University School of Medicine
Cecilia Hurtado: University of California, San Diego
Marta Diez-Cuñado: University of California, San Diego
Mingming Zhao: Stanford University School of Medicine
Sonomi Maruyama: Whitaker Cardiovascular Institute, Boston University School of Medicine
Wenhong Zhu: University of California, San Diego
Giovanni Fajardo: Stanford University School of Medicine
Michela Noseda: Imperial College London, Faculty of Medicine, Imperial Centre for Translational and Experimental Medicine
Kazuto Nakamura: Whitaker Cardiovascular Institute, Boston University School of Medicine
Xueying Tian: Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, and Shanghai Institutes for Biological Sciences, Graduate School of the Chinese Academy of Sciences, Chinese Academy of Sciences
Qiaozhen Liu: Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, and Shanghai Institutes for Biological Sciences, Graduate School of the Chinese Academy of Sciences, Chinese Academy of Sciences
Andrew Wang: Stanford University School of Medicine
Yuka Matsuura: Stanford University School of Medicine
Paul Bushway: University of California, San Diego
Wenqing Cai: University of California, San Diego
Alex Savchenko: University of California, San Diego
Morteza Mahmoudi: Stanford University School of Medicine
Michael D. Schneider: Imperial College London, Faculty of Medicine, Imperial Centre for Translational and Experimental Medicine
Maurice J. B. van den Hoff: Academic Medical Center. Dept Anatomy, Embryology and Physiology
Manish J. Butte: Stanford University School of Medicine
Phillip C. Yang: Stanford University School of Medicine
Kenneth Walsh: Whitaker Cardiovascular Institute, Boston University School of Medicine
Bin Zhou: Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, and Shanghai Institutes for Biological Sciences, Graduate School of the Chinese Academy of Sciences, Chinese Academy of Sciences
Daniel Bernstein: Stanford University School of Medicine
Mark Mercola: University of California, San Diego
Pilar Ruiz-Lozano: Stanford University School of Medicine

Nature, 2015, vol. 525, issue 7570, 479-485

Abstract: Abstract The elucidation of factors that activate the regeneration of the adult mammalian heart is of major scientific and therapeutic importance. Here we found that epicardial cells contain a potent cardiogenic activity identified as follistatin-like 1 (Fstl1). Epicardial Fstl1 declines following myocardial infarction and is replaced by myocardial expression. Myocardial Fstl1 does not promote regeneration, either basally or upon transgenic overexpression. Application of the human Fstl1 protein (FSTL1) via an epicardial patch stimulates cell cycle entry and division of pre-existing cardiomyocytes, improving cardiac function and survival in mouse and swine models of myocardial infarction. The data suggest that the loss of epicardial FSTL1 is a maladaptive response to injury, and that its restoration would be an effective way to reverse myocardial death and remodelling following myocardial infarction in humans.

Date: 2015
References: Add references at CitEc
Citations: View citations in EconPapers (1)

Downloads: (external link)
https://www.nature.com/articles/nature15372 Abstract (text/html)
Access to the full text of the articles in this series is restricted.

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:nature:v:525:y:2015:i:7570:d:10.1038_nature15372

Ordering information: This journal article can be ordered from
https://www.nature.com/

DOI: 10.1038/nature15372

Access Statistics for this article

Nature is currently edited by Magdalena Skipper

More articles in Nature from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().