Hallmarks of pluripotency

Alejandro De Los Angeles, Francesco Ferrari, Ruibin Xi, Yuko Fujiwara, Nissim Benvenisty, Hongkui Deng, Konrad Hochedlinger, Rudolf Jaenisch, Soohyun Lee, Harry G. Leitch, M. William Lensch, Ernesto Lujan, Duanqing Pei, Janet Rossant, Marius Wernig, Peter J. Park and George Q. Daley ()
Additional contact information
Alejandro De Los Angeles: Stem Cell Transplantation Program, Children’s Hospital Boston, Harvard Medical School
Francesco Ferrari: Harvard Medical School
Ruibin Xi: Harvard Medical School
Yuko Fujiwara: Stem Cell Transplantation Program, Children’s Hospital Boston, Harvard Medical School
Nissim Benvenisty: Stem Cell Unit, Institute of Life Sciences, The Hebrew University
Hongkui Deng: College of Life Sciences and Peking-Tsinghua Center for Life Sciences, Peking University
Konrad Hochedlinger: Harvard Stem Cell Institute
Rudolf Jaenisch: Whitehead Institute for Biomedical Research
Soohyun Lee: Harvard Medical School
Harry G. Leitch: Medical Research Council Clinical Sciences Centre, Imperial College London
M. William Lensch: Stem Cell Transplantation Program, Children’s Hospital Boston, Harvard Medical School
Ernesto Lujan: Institute for Stem Cell Biology and Regenerative Medicine, Stanford University
Duanqing Pei: South China Institute for Stem Cell Biology and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences
Janet Rossant: The Hospital for Sick Children Research Institute
Marius Wernig: Institute for Stem Cell Biology and Regenerative Medicine, Stanford University
Peter J. Park: Harvard Medical School
George Q. Daley: Stem Cell Transplantation Program, Children’s Hospital Boston, Harvard Medical School

Nature, 2015, vol. 525, issue 7570, 469-478

Abstract: In response to the need for a defined set of criteria to assess stem-cell potency, this review proposes guidelines for the evaluation of newly derived pluripotent stem cells, from functional assays to integrative molecular analyses of transcriptional, epigenetic and metabolic states.

Date: 2015
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DOI: 10.1038/nature15515

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