Deep imaging of bone marrow shows non-dividing stem cells are mainly perisinusoidal

Melih Acar, Kiranmai S. Kocherlakota, Malea M. Murphy, James G. Peyer, Hideyuki Oguro, Christopher N. Inra, Christabel Jaiyeola, Zhiyu Zhao, Katherine Luby-Phelps and Sean J. Morrison ()
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Melih Acar: University of Texas Southwestern Medical Center
Kiranmai S. Kocherlakota: Howard Hughes Medical Institute, University of Texas Southwestern Medical Center
Malea M. Murphy: University of Texas Southwestern Medical Center
James G. Peyer: University of Texas Southwestern Medical Center
Hideyuki Oguro: University of Texas Southwestern Medical Center
Christopher N. Inra: University of Texas Southwestern Medical Center
Christabel Jaiyeola: University of Texas Southwestern Medical Center
Zhiyu Zhao: University of Texas Southwestern Medical Center
Katherine Luby-Phelps: University of Texas Southwestern Medical Center
Sean J. Morrison: Howard Hughes Medical Institute, University of Texas Southwestern Medical Center

Nature, 2015, vol. 526, issue 7571, 126-130

Abstract: α-catulin is identified as a marker to locate functional haematopoiteic stem cells in deep imaging experiments of bone marrow, showing that α-catulin–GFP+c-kit+ cells commonly reside in perisinusoidal niches throughout the bone marrow.

Date: 2015
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DOI: 10.1038/nature15250

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