Multiple mechanisms for CRISPR–Cas inhibition by anti-CRISPR proteins

Joseph Bondy-Denomy, Bianca Garcia, Scott Strum, Mingjian Du, MaryClare F. Rollins, Yurima Hidalgo-Reyes, Blake Wiedenheft, Karen L. Maxwell () and Alan R. Davidson ()
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Joseph Bondy-Denomy: University of Toronto
Bianca Garcia: University of Toronto
Scott Strum: University of Toronto
Mingjian Du: University of Toronto
MaryClare F. Rollins: Montana State University
Yurima Hidalgo-Reyes: University of Toronto
Blake Wiedenheft: Montana State University
Karen L. Maxwell: Donnelly Centre for Cellular and Biomolecular Research, University of Toronto
Alan R. Davidson: University of Toronto

Nature, 2015, vol. 526, issue 7571, 136-139

Abstract: Bacterial cells evolved an immune system known as CRISPR–Cas to protect themselves from viral infection, triggering viruses to evolve anti-CRISPR proteins; here, three anti-CRISPR proteins are characterized, with each one interfering with the host CRISPR system at a different point.

Date: 2015
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DOI: 10.1038/nature15254

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