Single-cell analysis reveals a stem-cell program in human metastatic breast cancer cells

Devon A. Lawson, Nirav R. Bhakta, Kai Kessenbrock, Karin D. Prummel, Ying Yu, Ken Takai, Alicia Zhou, Henok Eyob, Sanjeev Balakrishnan, Chih-Yang Wang, Paul Yaswen, Andrei Goga () and Zena Werb ()
Additional contact information
Devon A. Lawson: University of California
Nirav R. Bhakta: University of California
Kai Kessenbrock: University of California
Karin D. Prummel: University of California
Ying Yu: University of California
Ken Takai: University of California
Alicia Zhou: University of California
Henok Eyob: University of California
Sanjeev Balakrishnan: University of California
Chih-Yang Wang: University of California
Paul Yaswen: Lawrence Berkeley National Laboratory
Andrei Goga: University of California
Zena Werb: University of California

Nature, 2015, vol. 526, issue 7571, 131-135

Abstract: Single-cell analysis of gene expression in metastatic cells from distinct human breast tumour models shows that early metastatic cells possess basal, stem and mesenchymal cell properties, whereas advanced metastatic cells have more proliferative properties and are more mature, enabling them to be targeted with an anti-proliferative compound.

Date: 2015
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DOI: 10.1038/nature15260

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