Nanoparticle biointerfacing by platelet membrane cloaking

Che-Ming J. Hu, Ronnie H. Fang, Kuei-Chun Wang, Brian T. Luk, Soracha Thamphiwatana, Diana Dehaini, Phu Nguyen, Pavimol Angsantikul, Cindy H. Wen, Ashley V. Kroll, Cody Carpenter, Manikantan Ramesh, Vivian Qu, Sherrina H. Patel, Jie Zhu, William Shi, Florence M. Hofman, Thomas C. Chen, Weiwei Gao, Kang Zhang (), Shu Chien () and Liangfang Zhang ()
Additional contact information
Che-Ming J. Hu: University of California, San Diego
Ronnie H. Fang: University of California, San Diego
Kuei-Chun Wang: University of California, San Diego
Brian T. Luk: Moores Cancer Center, University of California, San Diego
Soracha Thamphiwatana: University of California, San Diego
Diana Dehaini: University of California, San Diego
Phu Nguyen: University of California, San Diego
Pavimol Angsantikul: University of California, San Diego
Cindy H. Wen: Shiley Eye Institute, University of California, San Diego
Ashley V. Kroll: University of California, San Diego
Cody Carpenter: University of California, San Diego
Manikantan Ramesh: University of California, San Diego
Vivian Qu: University of California, San Diego
Sherrina H. Patel: Shiley Eye Institute, University of California, San Diego
Jie Zhu: Shiley Eye Institute, University of California, San Diego
William Shi: Shiley Eye Institute, University of California, San Diego
Florence M. Hofman: Keck School of Medicine, University of Southern California
Thomas C. Chen: Keck School of Medicine, University of Southern California
Weiwei Gao: University of California, San Diego
Kang Zhang: University of California, San Diego
Shu Chien: University of California, San Diego
Liangfang Zhang: University of California, San Diego

Nature, 2015, vol. 526, issue 7571, 118-121

Abstract: The authors report a new biomimetic nanodelivery platform in which polymeric nanoparticles enclosed in the plasma membrane of human platelets are used for disease-relevant targeting, and the therapeutic potential of the concept is demonstrated in animal models of coronary restenosis and systemic bacterial infection.

Date: 2015
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DOI: 10.1038/nature15373

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