Mediator kinase inhibition further activates super-enhancer-associated genes in AML

Henry E. Pelish, Brian B. Liau, Ioana I. Nitulescu, Anupong Tangpeerachaikul, Zachary C. Poss, Diogo H. Da Silva, Brittany T. Caruso, Alexander Arefolov, Olugbeminiyi Fadeyi, Amanda L. Christie, Karrie Du, Deepti Banka, Elisabeth V. Schneider, Anja Jestel, Ge Zou, Chong Si, Christopher C. Ebmeier, Roderick T. Bronson, Andrei V. Krivtsov, Andrew G. Myers, Nancy E. Kohl, Andrew L. Kung, Scott A. Armstrong, Madeleine E. Lemieux, Dylan J. Taatjes and Matthew D. Shair ()
Additional contact information
Henry E. Pelish: Harvard University
Brian B. Liau: Harvard University
Ioana I. Nitulescu: Harvard University
Anupong Tangpeerachaikul: Harvard University
Zachary C. Poss: University of Colorado
Diogo H. Da Silva: Harvard University
Brittany T. Caruso: Harvard University
Alexander Arefolov: Harvard University
Olugbeminiyi Fadeyi: Harvard University
Amanda L. Christie: Lurie Family Imaging Center, Dana-Farber Cancer Institute
Karrie Du: Harvard University
Deepti Banka: Children's Hospital
Elisabeth V. Schneider: Proteros Biostructures GmbH
Anja Jestel: Proteros Biostructures GmbH
Ge Zou: Harvard University
Chong Si: Harvard University
Christopher C. Ebmeier: University of Colorado
Roderick T. Bronson: Dana-Farber Cancer Institute
Andrei V. Krivtsov: Memorial Sloan Kettering Cancer Center
Andrew G. Myers: Harvard University
Nancy E. Kohl: Lurie Family Imaging Center, Dana-Farber Cancer Institute
Andrew L. Kung: Columbia University Medical Center
Scott A. Armstrong: Memorial Sloan Kettering Cancer Center
Madeleine E. Lemieux: Bioinfo
Dylan J. Taatjes: University of Colorado
Matthew D. Shair: Harvard University

Nature, 2015, vol. 526, issue 7572, 273-276

Abstract: A small-molecule inhibitor of the Mediator-associated kinases CDK8 and CDK19 inhibits growth of acute myeloid leukaemia (AML) cells and induces upregulation of super-enhancer-associated genes with tumour suppressor and lineage-controlling functions; Mediator kinase inhibition therefore represents a promising therapeutic approach for AML.

Date: 2015
References: Add references at CitEc
Citations: View citations in EconPapers (2)

Downloads: (external link)
https://www.nature.com/articles/nature14904 Abstract (text/html)
Access to the full text of the articles in this series is restricted.

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:nature:v:526:y:2015:i:7572:d:10.1038_nature14904

Ordering information: This journal article can be ordered from
https://www.nature.com/

DOI: 10.1038/nature14904

Access Statistics for this article

Nature is currently edited by Magdalena Skipper

More articles in Nature from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().