The genomic landscape of response to EGFR blockade in colorectal cancer

Andrea Bertotti (), Eniko Papp, Siân Jones, Vilmos Adleff, Valsamo Anagnostou, Barbara Lupo, Mark Sausen, Jillian Phallen, Carolyn A. Hruban, Collin Tokheim, Noushin Niknafs, Monica Nesselbush, Karli Lytle, Francesco Sassi, Francesca Cottino, Giorgia Migliardi, Eugenia R. Zanella, Dario Ribero, Nadia Russolillo, Alfredo Mellano, Andrea Muratore, Gianluca Paraluppi, Mauro Salizzoni, Silvia Marsoni, Michael Kragh, Johan Lantto, Andrea Cassingena, Qing Kay Li, Rachel Karchin, Robert Scharpf, Andrea Sartore-Bianchi, Salvatore Siena, Luis A. Diaz, Livio Trusolino () and Victor E. Velculescu ()
Additional contact information
Andrea Bertotti: University of Turin Medical School
Eniko Papp: Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine
Siân Jones: Personal Genome Diagnostics
Vilmos Adleff: Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine
Valsamo Anagnostou: Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine
Barbara Lupo: University of Turin Medical School
Mark Sausen: Personal Genome Diagnostics
Jillian Phallen: Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine
Carolyn A. Hruban: Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine
Collin Tokheim: Institute for Computational Medicine, Johns Hopkins University
Noushin Niknafs: Institute for Computational Medicine, Johns Hopkins University
Monica Nesselbush: Personal Genome Diagnostics
Karli Lytle: Personal Genome Diagnostics
Francesco Sassi: Translational Cancer Medicine, Surgical Oncology, and Clinical Trials Coordination, Candiolo Cancer Institute – Fondazione del Piemonte per l’Oncologia IRCCS
Francesca Cottino: Translational Cancer Medicine, Surgical Oncology, and Clinical Trials Coordination, Candiolo Cancer Institute – Fondazione del Piemonte per l’Oncologia IRCCS
Giorgia Migliardi: University of Turin Medical School
Eugenia R. Zanella: University of Turin Medical School
Dario Ribero: Mauriziano Umberto I Hospital
Nadia Russolillo: Mauriziano Umberto I Hospital
Alfredo Mellano: Translational Cancer Medicine, Surgical Oncology, and Clinical Trials Coordination, Candiolo Cancer Institute – Fondazione del Piemonte per l’Oncologia IRCCS
Andrea Muratore: Translational Cancer Medicine, Surgical Oncology, and Clinical Trials Coordination, Candiolo Cancer Institute – Fondazione del Piemonte per l’Oncologia IRCCS
Gianluca Paraluppi: Liver Transplantation Center, San Giovanni Battista Hospital
Mauro Salizzoni: Liver Transplantation Center, San Giovanni Battista Hospital
Silvia Marsoni: Translational Cancer Medicine, Surgical Oncology, and Clinical Trials Coordination, Candiolo Cancer Institute – Fondazione del Piemonte per l’Oncologia IRCCS
Michael Kragh: Symphogen A/S
Johan Lantto: Symphogen A/S
Andrea Cassingena: Niguarda Cancer Center, Ospedale Niguarda Ca’ Granda
Qing Kay Li: Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine
Rachel Karchin: Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine
Robert Scharpf: Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine
Andrea Sartore-Bianchi: Niguarda Cancer Center, Ospedale Niguarda Ca’ Granda
Salvatore Siena: Niguarda Cancer Center, Ospedale Niguarda Ca’ Granda
Luis A. Diaz: Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine
Livio Trusolino: University of Turin Medical School
Victor E. Velculescu: Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine

Nature, 2015, vol. 526, issue 7572, 263-267

Abstract: The effect of somatic genetic changes in colorectal cancer on sensitivity to anti-EGFR antibody therapy is analysed.

Date: 2015
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DOI: 10.1038/nature14969

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