η-Secretase processing of APP inhibits neuronal activity in the hippocampus

Michael Willem (), Sabina Tahirovic, Marc Aurel Busche, Saak V. Ovsepian, Magda Chafai, Scherazad Kootar, Daniel Hornburg, Lewis D. B. Evans, Steven Moore, Anna Daria, Heike Hampel, Veronika Müller, Camilla Giudici, Brigitte Nuscher, Andrea Wenninger-Weinzierl, Elisabeth Kremmer, Michael T. Heneka, Dietmar R. Thal, Vilmantas Giedraitis, Lars Lannfelt, Ulrike Müller, Frederick J. Livesey, Felix Meissner, Jochen Herms, Arthur Konnerth, Hélène Marie and Christian Haass ()
Additional contact information
Michael Willem: Biomedical Center (BMC), Ludwig-Maximilians-University Munich
Sabina Tahirovic: German Center for Neurodegenerative Diseases (DZNE) Munich
Marc Aurel Busche: Technische Universität München
Saak V. Ovsepian: German Center for Neurodegenerative Diseases (DZNE) Munich
Magda Chafai: Institut de Pharmacologie Moléculaire et Cellulaire (IPMC), Centre National de la Recherche Scientifique (CNRS), Université de Nice Sophia Antipolis
Scherazad Kootar: Institut de Pharmacologie Moléculaire et Cellulaire (IPMC), Centre National de la Recherche Scientifique (CNRS), Université de Nice Sophia Antipolis
Daniel Hornburg: Max Planck Institute of Biochemistry
Lewis D. B. Evans: Gurdon Institute, University of Cambridge
Steven Moore: Gurdon Institute, University of Cambridge
Anna Daria: Biomedical Center (BMC), Ludwig-Maximilians-University Munich
Heike Hampel: Biomedical Center (BMC), Ludwig-Maximilians-University Munich
Veronika Müller: Biomedical Center (BMC), Ludwig-Maximilians-University Munich
Camilla Giudici: Biomedical Center (BMC), Ludwig-Maximilians-University Munich
Brigitte Nuscher: Biomedical Center (BMC), Ludwig-Maximilians-University Munich
Andrea Wenninger-Weinzierl: German Center for Neurodegenerative Diseases (DZNE) Munich
Elisabeth Kremmer: German Center for Neurodegenerative Diseases (DZNE) Munich
Michael T. Heneka: Clinical Neuroscience Unit, University of Bonn
Dietmar R. Thal: Institute of Pathology - Laboratory for Neuropathology, University of Ulm
Vilmantas Giedraitis: Uppsala University
Lars Lannfelt: Uppsala University
Ulrike Müller: Institute for Pharmacy and Molecular Biotechnology IPMB, Functional Genomics, University of Heidelberg
Frederick J. Livesey: Gurdon Institute, University of Cambridge
Felix Meissner: Max Planck Institute of Biochemistry
Jochen Herms: German Center for Neurodegenerative Diseases (DZNE) Munich
Arthur Konnerth: Institute of Neuroscience, Technische Universität München
Hélène Marie: Institut de Pharmacologie Moléculaire et Cellulaire (IPMC), Centre National de la Recherche Scientifique (CNRS), Université de Nice Sophia Antipolis
Christian Haass: Biomedical Center (BMC), Ludwig-Maximilians-University Munich

Nature, 2015, vol. 526, issue 7573, 443-447

Abstract: A new pathway for the processing of β-amyloid precursor protein (APP) is described in which η-secretase activity, in part mediated by the MT5-MMP metalloproteinase, cleaves APP, and further processing by ADAM10 and BACE1 generates proteolytic fragments capable of inhibiting long-term potentiation in the hippocampus.

Date: 2015
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DOI: 10.1038/nature14864

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