Inhibition of Gli1 mobilizes endogenous neural stem cells for remyelination

Jayshree Samanta (), Ethan M. Grund, Hernandez M. Silva, Juan J. Lafaille, Gord Fishell and James L. Salzer ()
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Jayshree Samanta: New York University Neuroscience Institute, New York University School of Medicine
Ethan M. Grund: New York University Neuroscience Institute, New York University School of Medicine
Hernandez M. Silva: The Kimmel Center for Biology and Medicine of the Skirball Institute, New York University School of Medicine
Juan J. Lafaille: The Kimmel Center for Biology and Medicine of the Skirball Institute, New York University School of Medicine
Gord Fishell: New York University Neuroscience Institute, New York University School of Medicine
James L. Salzer: New York University Neuroscience Institute, New York University School of Medicine

Nature, 2015, vol. 526, issue 7573, 448-452

Abstract: A subset of adult neural stem cells, responsive to sonic hedgehog, are more effective at remyelination when the transcription factor Gli1 is inhibited.

Date: 2015
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DOI: 10.1038/nature14957

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