Forniceal deep brain stimulation rescues hippocampal memory in Rett syndrome mice

Shuang Hao, Bin Tang, Zhenyu Wu, Kerstin Ure, Yaling Sun, Huifang Tao, Yan Gao, Akash J. Patel, Daniel J. Curry, Rodney C. Samaco, Huda Y. Zoghbi () and Jianrong Tang ()
Additional contact information
Shuang Hao: Jan and Dan Duncan Neurological Research Institute, Texas Children’s Hospital
Bin Tang: Jan and Dan Duncan Neurological Research Institute, Texas Children’s Hospital
Zhenyu Wu: Jan and Dan Duncan Neurological Research Institute, Texas Children’s Hospital
Kerstin Ure: Jan and Dan Duncan Neurological Research Institute, Texas Children’s Hospital
Yaling Sun: Jan and Dan Duncan Neurological Research Institute, Texas Children’s Hospital
Huifang Tao: Jan and Dan Duncan Neurological Research Institute, Texas Children’s Hospital
Yan Gao: Jan and Dan Duncan Neurological Research Institute, Texas Children’s Hospital
Akash J. Patel: Jan and Dan Duncan Neurological Research Institute, Texas Children’s Hospital
Daniel J. Curry: Baylor College of Medicine
Rodney C. Samaco: Jan and Dan Duncan Neurological Research Institute, Texas Children’s Hospital
Huda Y. Zoghbi: Jan and Dan Duncan Neurological Research Institute, Texas Children’s Hospital
Jianrong Tang: Jan and Dan Duncan Neurological Research Institute, Texas Children’s Hospital

Nature, 2015, vol. 526, issue 7573, 430-434

Abstract: Deep brain stimulation (DBS) of the fimbria–fornix—a region that provides input to the hippocampus—is shown to restore hippocampus-dependent memory and hippocampal long-term potentiation and neurogenesis in a mouse model of Rett syndrome, suggesting that DBS, which is already used in the treatment of several neurological conditions, could be a viable approach to mitigating cognitive impairment in Rett syndrome and other disorders of childhood intellectual disability.

Date: 2015
References: Add references at CitEc
Citations: View citations in EconPapers (2)

Downloads: (external link)
https://www.nature.com/articles/nature15694 Abstract (text/html)
Access to the full text of the articles in this series is restricted.

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:nature:v:526:y:2015:i:7573:d:10.1038_nature15694

Ordering information: This journal article can be ordered from
https://www.nature.com/

DOI: 10.1038/nature15694

Access Statistics for this article

Nature is currently edited by Magdalena Skipper

More articles in Nature from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().