RAF inhibitors that evade paradoxical MAPK pathway activation

Chao Zhang (), Wayne Spevak, Ying Zhang, Elizabeth A. Burton, Yan Ma, Gaston Habets, Jiazhong Zhang, Jack Lin, Todd Ewing, Bernice Matusow, Garson Tsang, Adhirai Marimuthu, Hanna Cho, Guoxian Wu, Weiru Wang, Daniel Fong, Hoa Nguyen, Songyuan Shi, Patrick Womack, Marika Nespi, Rafe Shellooe, Heidi Carias, Ben Powell, Emily Light, Laura Sanftner, Jason Walters, James Tsai, Brian L. West, Gary Visor, Hamid Rezaei, Paul S. Lin, Keith Nolop, Prabha N. Ibrahim, Peter Hirth and Gideon Bollag ()
Additional contact information
Chao Zhang: Plexxikon Inc.
Wayne Spevak: Plexxikon Inc.
Ying Zhang: Plexxikon Inc.
Elizabeth A. Burton: Plexxikon Inc.
Yan Ma: Plexxikon Inc.
Gaston Habets: Plexxikon Inc.
Jiazhong Zhang: Plexxikon Inc.
Jack Lin: Plexxikon Inc.
Todd Ewing: Plexxikon Inc.
Bernice Matusow: Plexxikon Inc.
Garson Tsang: Plexxikon Inc.
Adhirai Marimuthu: Plexxikon Inc.
Hanna Cho: Plexxikon Inc.
Guoxian Wu: Plexxikon Inc.
Weiru Wang: Plexxikon Inc.
Daniel Fong: Plexxikon Inc.
Hoa Nguyen: Plexxikon Inc.
Songyuan Shi: Plexxikon Inc.
Patrick Womack: Plexxikon Inc.
Marika Nespi: Plexxikon Inc.
Rafe Shellooe: Plexxikon Inc.
Heidi Carias: Plexxikon Inc.
Ben Powell: Plexxikon Inc.
Emily Light: Plexxikon Inc.
Laura Sanftner: Plexxikon Inc.
Jason Walters: Plexxikon Inc.
James Tsai: Plexxikon Inc.
Brian L. West: Plexxikon Inc.
Gary Visor: Plexxikon Inc.
Hamid Rezaei: Plexxikon Inc.
Paul S. Lin: Plexxikon Inc.
Keith Nolop: Plexxikon Inc.
Prabha N. Ibrahim: Plexxikon Inc.
Peter Hirth: Plexxikon Inc.
Gideon Bollag: Plexxikon Inc.

Nature, 2015, vol. 526, issue 7574, 583-586

Abstract: Next-generation RAF inhibitors that inhibit oncogenic BRAF without inducing paradoxical pathway activation in cells with mutant RAS might yield improved safety and more durable efficacy.

Date: 2015
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DOI: 10.1038/nature14982

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