Hedgehog actively maintains adult lung quiescence and regulates repair and regeneration

Tien Peng (), David B. Frank, Rachel S. Kadzik, Michael P. Morley, Komal S. Rathi, Tao Wang, Su Zhou, Lan Cheng, Min Min Lu and Edward E. Morrisey ()
Additional contact information
Tien Peng: University of Pennsylvania
David B. Frank: University of Pennsylvania
Rachel S. Kadzik: University of Pennsylvania
Michael P. Morley: University of Pennsylvania
Komal S. Rathi: University of Pennsylvania
Tao Wang: Penn Cardiovascular Institute, University of Pennsylvania
Su Zhou: Penn Cardiovascular Institute, University of Pennsylvania
Lan Cheng: Penn Cardiovascular Institute, University of Pennsylvania
Min Min Lu: Penn Cardiovascular Institute, University of Pennsylvania
Edward E. Morrisey: University of Pennsylvania

Nature, 2015, vol. 526, issue 7574, 578-582

Abstract: It is generally thought that the quiescence of tissue is not actively maintained, but rather a state reflecting the absence of proliferative signal; here the authors find that quiescence is actively maintained by paracrine hedgehog signalling provided by the epithelium in the mouse adult lung, and that hedgehog is dynamically regulated during injury repair and resolution for proper restoration of tissue homeostasis after injury.

Date: 2015
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DOI: 10.1038/nature14984

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