Dynamic m6A mRNA methylation directs translational control of heat shock response

Jun Zhou, Ji Wan, Xiangwei Gao, Xingqian Zhang, Samie R. Jaffrey and Shu-Bing Qian ()
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Jun Zhou: Cornell University
Ji Wan: Cornell University
Xiangwei Gao: Cornell University
Xingqian Zhang: Cornell University
Samie R. Jaffrey: Weill Cornell Medical College, Cornell University
Shu-Bing Qian: Cornell University

Nature, 2015, vol. 526, issue 7574, 591-594

Abstract: Under stress, such as heat shock, the N6-methyladenosine (m6A) modification is shown to accumulate primarily in the 5′ untranslated region of induced mRNAs owing to the translocation of an m6A interacting protein, YTHDF2, into the nucleus, resulting in increased cap-independent translation of these mRNAs, indicating one possible mechanism by which stress-responsive genes can be preferentially expressed.

Date: 2015
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DOI: 10.1038/nature15377

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