Kidney organoids from human iPS cells contain multiple lineages and model human nephrogenesis

Minoru Takasato (), Pei X. Er, Han S. Chiu, Barbara Maier, Gregory J. Baillie, Charles Ferguson, Robert G. Parton, Ernst J. Wolvetang, Matthias S. Roost, Susana M. Chuva de Sousa Lopes and Melissa H. Little ()
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Minoru Takasato: Murdoch Childrens Research Institute, The Royal Children's Hospital Melbourne
Pei X. Er: Murdoch Childrens Research Institute, The Royal Children's Hospital Melbourne
Han S. Chiu: Institute for Molecular Bioscience, The University of Queensland
Barbara Maier: Institute for Molecular Bioscience, The University of Queensland
Gregory J. Baillie: Institute for Molecular Bioscience, The University of Queensland
Charles Ferguson: Institute for Molecular Bioscience, The University of Queensland
Robert G. Parton: Institute for Molecular Bioscience, The University of Queensland
Ernst J. Wolvetang: Australian Institute for Bioengineering and Nanotechnology, The University of Queensland
Matthias S. Roost: Leiden University Medical Center
Susana M. Chuva de Sousa Lopes: Leiden University Medical Center
Melissa H. Little: Murdoch Childrens Research Institute, The Royal Children's Hospital Melbourne

Nature, 2015, vol. 526, issue 7574, 564-568

Abstract: The kidney arises from two types of progenitors; here, the signalling conditions that induce the production of collecting ducts and functional nephrons from human pluripotent stem cells are determined, and organoids that recapitulate the functional regionalization of the kidney are produced.

Date: 2015
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DOI: 10.1038/nature15695

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