Telomerase activation by genomic rearrangements in high-risk neuroblastoma

Martin Peifer (), Falk Hertwig, Frederik Roels, Daniel Dreidax, Moritz Gartlgruber, Roopika Menon, Andrea Krämer, Justin L. Roncaioli, Frederik Sand, Johannes M. Heuckmann, Fakhera Ikram, Rene Schmidt, Sandra Ackermann, Anne Engesser, Yvonne Kahlert, Wenzel Vogel, Janine Altmüller, Peter Nürnberg, Jean Thierry-Mieg, Danielle Thierry-Mieg, Aruljothi Mariappan, Stefanie Heynck, Erika Mariotti, Kai-Oliver Henrich, Christian Gloeckner, Graziella Bosco, Ivo Leuschner, Michal R. Schweiger, Larissa Savelyeva, Simon C. Watkins, Chunxuan Shao, Emma Bell, Thomas Höfer, Viktor Achter, Ulrich Lang, Jessica Theissen, Ruth Volland, Maral Saadati, Angelika Eggert, Bram de Wilde, Frank Berthold, Zhiyu Peng, Chen Zhao, Leming Shi, Monika Ortmann, Reinhard Büttner, Sven Perner, Barbara Hero, Alexander Schramm, Johannes H. Schulte, Carl Herrmann, Roderick J. O’Sullivan, Frank Westermann (), Roman K. Thomas () and Matthias Fischer ()
Additional contact information
Martin Peifer: Center of Integrated Oncology Cologne–Bonn, Medical Faculty, University of Cologne
Falk Hertwig: Center for Molecular Medicine Cologne (CMMC), University of Cologne
Frederik Roels: Center for Molecular Medicine Cologne (CMMC), University of Cologne
Daniel Dreidax: German Cancer Research Center
Moritz Gartlgruber: German Cancer Research Center
Roopika Menon: Institute of Pathology, Center for Integrated Oncology Cologne-Bonn, University Hospital of Bonn
Andrea Krämer: Center for Molecular Medicine Cologne (CMMC), University of Cologne
Justin L. Roncaioli: University of Pittsburgh Cancer Institute (UPCI), Hillman Cancer Center
Frederik Sand: Center for Molecular Medicine Cologne (CMMC), University of Cologne
Johannes M. Heuckmann: NEO New Oncology AG
Fakhera Ikram: Center for Molecular Medicine Cologne (CMMC), University of Cologne
Rene Schmidt: Institute of Biostatistics and Clinical Research, University of Münster
Sandra Ackermann: Center for Molecular Medicine Cologne (CMMC), University of Cologne
Anne Engesser: University Children’s Hospital of Cologne, Medical Faculty, University of Cologne
Yvonne Kahlert: University Children’s Hospital of Cologne, Medical Faculty, University of Cologne
Wenzel Vogel: Institute of Pathology, Center for Integrated Oncology Cologne-Bonn, University Hospital of Bonn
Janine Altmüller: Cologne Center for Genomics, University of Cologne
Peter Nürnberg: Center for Molecular Medicine Cologne (CMMC), University of Cologne
Jean Thierry-Mieg: National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health
Danielle Thierry-Mieg: National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health
Aruljothi Mariappan: Center for Molecular Medicine Cologne (CMMC), University of Cologne
Stefanie Heynck: NEO New Oncology AG
Erika Mariotti: NEO New Oncology AG
Kai-Oliver Henrich: German Cancer Research Center
Christian Gloeckner: NEO New Oncology AG
Graziella Bosco: Center of Integrated Oncology Cologne–Bonn, Medical Faculty, University of Cologne
Ivo Leuschner: University of Kiel
Michal R. Schweiger: Functional Epigenomics, University of Cologne
Larissa Savelyeva: German Cancer Research Center
Simon C. Watkins: Center for Biologic Imaging, University of Pittsburgh
Chunxuan Shao: German Cancer Research Center (DKFZ)
Emma Bell: German Cancer Research Center
Thomas Höfer: German Cancer Research Center (DKFZ)
Viktor Achter: Computing Center, University of Cologne
Ulrich Lang: Computing Center, University of Cologne
Jessica Theissen: University Children’s Hospital of Cologne, Medical Faculty, University of Cologne
Ruth Volland: University Children’s Hospital of Cologne, Medical Faculty, University of Cologne
Maral Saadati: German Cancer Research Center (DKFZ)
Angelika Eggert: Charité University Medical Center Berlin
Bram de Wilde: Center for Medical Genetics, Ghent University
Frank Berthold: University Children’s Hospital of Cologne, Medical Faculty, University of Cologne
Zhiyu Peng: BGI-Shenzhen, Bei Shan Industrial Zone, Yantian District
Chen Zhao: Center for Pharmacogenomics and Fudan-Zhangjiang Center for Clinical Genomics, State Key Laboratory of Genetic Engineering and MOE Key Laboratory of Contemporary Anthropology School of Pharmacy and School of Life Sciences, Fudan University
Leming Shi: Center for Pharmacogenomics and Fudan-Zhangjiang Center for Clinical Genomics, State Key Laboratory of Genetic Engineering and MOE Key Laboratory of Contemporary Anthropology School of Pharmacy and School of Life Sciences, Fudan University
Monika Ortmann: University of Cologne
Reinhard Büttner: University of Cologne
Sven Perner: Institute of Pathology, Center for Integrated Oncology Cologne-Bonn, University Hospital of Bonn
Barbara Hero: University Children’s Hospital of Cologne, Medical Faculty, University of Cologne
Alexander Schramm: University Children’s Hospital
Johannes H. Schulte: Charité University Medical Center Berlin
Carl Herrmann: Institute of Pharmacy and Molecular Biotechnology, University of Heidelberg
Roderick J. O’Sullivan: University of Pittsburgh Cancer Institute (UPCI), Hillman Cancer Center
Frank Westermann: German Cancer Research Center
Roman K. Thomas: Center of Integrated Oncology Cologne–Bonn, Medical Faculty, University of Cologne
Matthias Fischer: Center for Molecular Medicine Cologne (CMMC), University of Cologne

Nature, 2015, vol. 526, issue 7575, 700-704

Abstract: Activation of telomere maintenance mechanisms—caused by novel somatic rearrangements of TERT, by MYCN amplification, or ATRX mutations—is a hallmark of high-risk neuroblastomas.

Date: 2015
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DOI: 10.1038/nature14980

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