Crystal structure of the 500-kDa yeast acetyl-CoA carboxylase holoenzyme dimer

Jia Wei and Liang Tong ()
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Jia Wei: Columbia University
Liang Tong: Columbia University

Nature, 2015, vol. 526, issue 7575, 723-727

Abstract: Acetyl-CoA carboxylases (ACCs) are large, multi-domain enzymes with crucial functions in fatty acid metabolism and are potential drug targets; here the X-ray crystal structure of the full-length, 500-kDa holoenzyme dimer of the ACC from Saccharomyces cerevisiae is solved and reveals an organization quite different from that of other biotin-dependent carboxylases.

Date: 2015
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DOI: 10.1038/nature15375

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