Yap-dependent reprogramming of Lgr5+ stem cells drives intestinal regeneration and cancer

Alex Gregorieff, Yu Liu, Mohammad R. Inanlou, Yuliya Khomchuk and Jeffrey L. Wrana ()
Additional contact information
Alex Gregorieff: Centre for Systems Biology, Lunenfeld Tanenbaum Research Institute, Mount Sinai Hospital
Yu Liu: Centre for Systems Biology, Lunenfeld Tanenbaum Research Institute, Mount Sinai Hospital
Mohammad R. Inanlou: Centre for Systems Biology, Lunenfeld Tanenbaum Research Institute, Mount Sinai Hospital
Yuliya Khomchuk: Centre for Systems Biology, Lunenfeld Tanenbaum Research Institute, Mount Sinai Hospital
Jeffrey L. Wrana: Centre for Systems Biology, Lunenfeld Tanenbaum Research Institute, Mount Sinai Hospital

Nature, 2015, vol. 526, issue 7575, 715-718

Abstract: This study finds that the Hippo pathway is essential for gut epithelial regeneration and tumour initiation; the Hippo component Yap holds off differentiation of intestinal stem cells to Paneth cells to promote a survival and self-renewal regenerative program through activation of the Egfr pathway.

Date: 2015
References: Add references at CitEc
Citations: View citations in EconPapers (11)

Downloads: (external link)
https://www.nature.com/articles/nature15382 Abstract (text/html)
Access to the full text of the articles in this series is restricted.

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:nature:v:526:y:2015:i:7575:d:10.1038_nature15382

Ordering information: This journal article can be ordered from
https://www.nature.com/

DOI: 10.1038/nature15382

Access Statistics for this article

Nature is currently edited by Magdalena Skipper

More articles in Nature from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().