Bacteriocin production augments niche competition by enterococci in the mammalian gastrointestinal tract

Sushma Kommineni, Daniel J. Bretl, Vy Lam, Rajrupa Chakraborty, Michael Hayward, Pippa Simpson, Yumei Cao, Pavlos Bousounis, Christopher J. Kristich () and Nita H. Salzman ()
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Sushma Kommineni: Medical College of Wisconsin
Daniel J. Bretl: Medical College of Wisconsin
Vy Lam: Medical College of Wisconsin
Rajrupa Chakraborty: Medical College of Wisconsin
Michael Hayward: Medical College of Wisconsin
Pippa Simpson: Medical College of Wisconsin
Yumei Cao: Medical College of Wisconsin
Pavlos Bousounis: Medical College of Wisconsin
Christopher J. Kristich: Medical College of Wisconsin
Nita H. Salzman: Medical College of Wisconsin

Nature, 2015, vol. 526, issue 7575, 719-722

Abstract: The authors develop a mouse model of Enterococcus faecalis colonization to show that enterococci harbouring the bacteriocin-expressing plasmid pPD1 replace indigenous enterococci and have the ability to transfer the plasmid to other enterococci, which enhances the stability of the bacteriocin-expressing bacteria in the gut; this result suggests a therapeutic approach that leverages niche-specificity to eliminate antibiotic-resistant bacteria from infected individuals.

Date: 2015
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DOI: 10.1038/nature15524

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