Microenvironment-induced PTEN loss by exosomal microRNA primes brain metastasis outgrowth

Lin Zhang, Siyuan Zhang, Jun Yao, Frank J. Lowery, Qingling Zhang, Wen-Chien Huang, Ping Li, Min Li, Xiao Wang, Chenyu Zhang, Hai Wang, Kenneth Ellis, Mujeeburahiman Cheerathodi, Joseph H. McCarty, Diane Palmieri, Jodi Saunus, Sunil Lakhani, Suyun Huang, Aysegul A. Sahin, Kenneth D. Aldape, Patricia S. Steeg and Dihua Yu ()
Additional contact information
Lin Zhang: The University of Texas M. D. Anderson Cancer Center
Siyuan Zhang: The University of Texas M. D. Anderson Cancer Center
Jun Yao: The University of Texas M. D. Anderson Cancer Center
Frank J. Lowery: The University of Texas M. D. Anderson Cancer Center
Qingling Zhang: The University of Texas M. D. Anderson Cancer Center
Wen-Chien Huang: The University of Texas M. D. Anderson Cancer Center
Ping Li: The University of Texas M. D. Anderson Cancer Center
Min Li: The University of Texas M. D. Anderson Cancer Center
Xiao Wang: The University of Texas M. D. Anderson Cancer Center
Chenyu Zhang: The University of Texas M. D. Anderson Cancer Center
Hai Wang: The University of Texas M. D. Anderson Cancer Center
Kenneth Ellis: The University of Texas M. D. Anderson Cancer Center
Mujeeburahiman Cheerathodi: The University of Texas M. D. Anderson Cancer Center
Joseph H. McCarty: The University of Texas M. D. Anderson Cancer Center
Diane Palmieri: Woman’s Malignancies Branch, National Cancer Institute
Jodi Saunus: The University of Queensland Centre for Clinical Research
Sunil Lakhani: The University of Queensland Centre for Clinical Research
Suyun Huang: The University of Texas M. D. Anderson Cancer Center
Aysegul A. Sahin: The University of Texas M. D. Anderson Cancer Center
Kenneth D. Aldape: The University of Texas M. D. Anderson Cancer Center
Patricia S. Steeg: Woman’s Malignancies Branch, National Cancer Institute
Dihua Yu: The University of Texas M. D. Anderson Cancer Center

Nature, 2015, vol. 527, issue 7576, 100-104

Abstract: Expression of the tumour suppressor PTEN in disseminated primary tumour cells is lost after tumour cells metastasize to the brain, with downregulation instigated by microRNAs from astrocytes, which are transferred from cell to cell by exosomes; these findings reveal the dynamic nature of metastatic cancer cells when adapting to a new tissue environment.

Date: 2015
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DOI: 10.1038/nature15376

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