Differential responses to lithium in hyperexcitable neurons from patients with bipolar disorder

Jerome Mertens, Qiu-Wen Wang, Yongsung Kim, Diana X. Yu, Son Pham, Bo Yang, Yi Zheng, Kenneth E. Diffenderfer, Jian Zhang, Sheila Soltani, Tameji Eames, Simon T. Schafer, Leah Boyer, Maria C. Marchetto, John I. Nurnberger, Joseph R. Calabrese, Ketil J. Oedegaard, Michael J. McCarthy, Peter P. Zandi, Martin Alda, Caroline M. Nievergelt, Shuangli Mi, Kristen J. Brennand, John R. Kelsoe (), Fred H. Gage () and Jun Yao ()
Additional contact information
Jerome Mertens: State Key Laboratory of Membrane Biology, Tsinghua-Peking Joint Center for Life Sciences, McGovern Institute for Brain Research, School of Life Sciences, Tsinghua University
Qiu-Wen Wang: State Key Laboratory of Membrane Biology, Tsinghua-Peking Joint Center for Life Sciences, McGovern Institute for Brain Research, School of Life Sciences, Tsinghua University
Yongsung Kim: The Salk Institute for Biological Studies, Laboratory of Genetics
Diana X. Yu: The Salk Institute for Biological Studies, Laboratory of Genetics
Son Pham: The Salk Institute for Biological Studies, Laboratory of Genetics
Bo Yang: State Key Laboratory of Membrane Biology, Tsinghua-Peking Joint Center for Life Sciences, McGovern Institute for Brain Research, School of Life Sciences, Tsinghua University
Yi Zheng: State Key Laboratory of Membrane Biology, Tsinghua-Peking Joint Center for Life Sciences, McGovern Institute for Brain Research, School of Life Sciences, Tsinghua University
Kenneth E. Diffenderfer: The Salk Institute for Biological Studies, Stem Cell Core
Jian Zhang: Key Laboratory of Genomic and Precision Medicine, Beijing Institute of Genomics, Chinese Academy of Sciences
Sheila Soltani: The Salk Institute for Biological Studies, Laboratory of Genetics
Tameji Eames: The Salk Institute for Biological Studies, Laboratory of Genetics
Simon T. Schafer: The Salk Institute for Biological Studies, Laboratory of Genetics
Leah Boyer: The Salk Institute for Biological Studies, Laboratory of Genetics
Maria C. Marchetto: The Salk Institute for Biological Studies, Laboratory of Genetics
John I. Nurnberger: Indiana University
Joseph R. Calabrese: Case Western Reserve University
Ketil J. Oedegaard: Section for Psychiatry, University of Bergen and K.G. Jebsen Centre for Research on Neuropsychiatric Disorders
Michael J. McCarthy: VA San Diego Healthcare System
Peter P. Zandi: Johns Hopkins University
Martin Alda: Dalhousie University
Caroline M. Nievergelt: University of California San Diego
Shuangli Mi: Key Laboratory of Genomic and Precision Medicine, Beijing Institute of Genomics, Chinese Academy of Sciences
Kristen J. Brennand: Mount Sinai School of Medicine
John R. Kelsoe: VA San Diego Healthcare System
Fred H. Gage: The Salk Institute for Biological Studies, Laboratory of Genetics
Jun Yao: State Key Laboratory of Membrane Biology, Tsinghua-Peking Joint Center for Life Sciences, McGovern Institute for Brain Research, School of Life Sciences, Tsinghua University

Nature, 2015, vol. 527, issue 7576, 95-99

Abstract: A neuronal model of bipolar disorder based on induced pluripotent stem cell (iPSC) technology finds hyperactive action-potential firing and differential responsiveness to lithium in iPSC-derived neurons from patients with bipolar disorder.

Date: 2015
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DOI: 10.1038/nature15526

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