Autophagy mediates degradation of nuclear lamina

Zhixun Dou, Caiyue Xu, Greg Donahue, Takeshi Shimi, Ji-An Pan, Jiajun Zhu, Andrejs Ivanov, Brian C. Capell, Adam M. Drake, Parisha P. Shah, Joseph M. Catanzaro, M. Daniel Ricketts, Trond Lamark, Stephen A. Adam, Ronen Marmorstein, Wei-Xing Zong, Terje Johansen, Robert D. Goldman, Peter D. Adams and Shelley L. Berger ()
Additional contact information
Zhixun Dou: Epigenetics Program, Perelman School of Medicine, University of Pennsylvania
Caiyue Xu: Epigenetics Program, Perelman School of Medicine, University of Pennsylvania
Greg Donahue: Epigenetics Program, Perelman School of Medicine, University of Pennsylvania
Takeshi Shimi: Feinberg School of Medicine, Northwestern University
Ji-An Pan: Stony Brook University
Jiajun Zhu: Epigenetics Program, Perelman School of Medicine, University of Pennsylvania
Andrejs Ivanov: Institute of Cancer Sciences, University of Glasgow and Beatson Institute for Cancer Research
Brian C. Capell: Epigenetics Program, Perelman School of Medicine, University of Pennsylvania
Adam M. Drake: Epigenetics Program, Perelman School of Medicine, University of Pennsylvania
Parisha P. Shah: Epigenetics Program, Perelman School of Medicine, University of Pennsylvania
Joseph M. Catanzaro: Stony Brook University
M. Daniel Ricketts: University of Pennsylvania
Trond Lamark: Molecular Cancer Research Group, Institute of Medical Biology, University of Tromsø – The Arctic University of Norway
Stephen A. Adam: Feinberg School of Medicine, Northwestern University
Ronen Marmorstein: University of Pennsylvania
Wei-Xing Zong: Stony Brook University
Terje Johansen: Molecular Cancer Research Group, Institute of Medical Biology, University of Tromsø – The Arctic University of Norway
Robert D. Goldman: Feinberg School of Medicine, Northwestern University
Peter D. Adams: Institute of Cancer Sciences, University of Glasgow and Beatson Institute for Cancer Research
Shelley L. Berger: Epigenetics Program, Perelman School of Medicine, University of Pennsylvania

Nature, 2015, vol. 527, issue 7576, 105-109

Abstract: In response to cancer-associated stress, autophagy machinery mediates degradation of nuclear lamina components in mammals, suggesting that cells might degrade nuclear components to prevent tumorigenesis.

Date: 2015
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DOI: 10.1038/nature15548

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