Structural insight into substrate preference for TET-mediated oxidation

Lulu Hu, Junyan Lu, Jingdong Cheng, Qinhui Rao, Ze Li, Haifeng Hou, Zhiyong Lou, Lei Zhang, Wei Li, Wei Gong, Mengjie Liu, Chang Sun, Xiaotong Yin, Jie Li, Xiangshi Tan, Pengcheng Wang, Yinsheng Wang, Dong Fang, Qiang Cui, Pengyuan Yang, Chuan He, Hualiang Jiang, Cheng Luo () and Yanhui Xu ()
Additional contact information
Lulu Hu: Fudan University Shanghai Cancer Center, Institute of Biomedical Sciences, Shanghai Medical College of Fudan University
Junyan Lu: Drug Discovery and Design Center, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences
Jingdong Cheng: Fudan University Shanghai Cancer Center, Institute of Biomedical Sciences, Shanghai Medical College of Fudan University
Qinhui Rao: Fudan University Shanghai Cancer Center, Institute of Biomedical Sciences, Shanghai Medical College of Fudan University
Ze Li: Fudan University Shanghai Cancer Center, Institute of Biomedical Sciences, Shanghai Medical College of Fudan University
Haifeng Hou: Beijing Synchrotron Radiation Facility, Institute of High Energy Physics, Chinese Academy of Sciences
Zhiyong Lou: Laboratory of Structural Biology, Tsinghua University
Lei Zhang: Fudan University Shanghai Cancer Center, Institute of Biomedical Sciences, Shanghai Medical College of Fudan University
Wei Li: Fudan University Shanghai Cancer Center, Institute of Biomedical Sciences, Shanghai Medical College of Fudan University
Wei Gong: Fudan University Shanghai Cancer Center, Institute of Biomedical Sciences, Shanghai Medical College of Fudan University
Mengjie Liu: Fudan University Shanghai Cancer Center, Institute of Biomedical Sciences, Shanghai Medical College of Fudan University
Chang Sun: Fudan University Shanghai Cancer Center, Institute of Biomedical Sciences, Shanghai Medical College of Fudan University
Xiaotong Yin: Fudan University Shanghai Cancer Center, Institute of Biomedical Sciences, Shanghai Medical College of Fudan University
Jie Li: Fudan University Shanghai Cancer Center, Institute of Biomedical Sciences, Shanghai Medical College of Fudan University
Xiangshi Tan: Fudan University Shanghai Cancer Center, Institute of Biomedical Sciences, Shanghai Medical College of Fudan University
Pengcheng Wang: University of California-Riverside
Yinsheng Wang: University of California-Riverside
Dong Fang: Theoretical Chemistry Institute, University of Wisconsin-Madison, 1101 University Avenue
Qiang Cui: Theoretical Chemistry Institute, University of Wisconsin-Madison, 1101 University Avenue
Pengyuan Yang: Fudan University Shanghai Cancer Center, Institute of Biomedical Sciences, Shanghai Medical College of Fudan University
Chuan He: The University of Chicago
Hualiang Jiang: Drug Discovery and Design Center, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences
Cheng Luo: Drug Discovery and Design Center, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences
Yanhui Xu: Fudan University Shanghai Cancer Center, Institute of Biomedical Sciences, Shanghai Medical College of Fudan University

Nature, 2015, vol. 527, issue 7576, 118-122

Abstract: In DNA demethylation, human TET proteins are evolutionarily tuned to be less reactive towards 5hmC and facilitate its generation as a potentially stable mark for regulatory functions.

Date: 2015
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DOI: 10.1038/nature15713

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