Epigenetic silencing of TH1-type chemokines shapes tumour immunity and immunotherapy

Dongjun Peng, Ilona Kryczek, Nisha Nagarsheth, Lili Zhao, Shuang Wei, Weimin Wang, Yuqing Sun, Ende Zhao, Linda Vatan, Wojciech Szeliga, Jan Kotarski, Rafał Tarkowski, Yali Dou, Kathleen Cho, Sharon Hensley-Alford, Adnan Munkarah, Rebecca Liu and Weiping Zou ()
Additional contact information
Dongjun Peng: University of Michigan School of Medicine
Ilona Kryczek: University of Michigan School of Medicine
Nisha Nagarsheth: University of Michigan School of Medicine
Lili Zhao: University of Michigan School of Medicine
Shuang Wei: University of Michigan School of Medicine
Weimin Wang: University of Michigan School of Medicine
Yuqing Sun: University of Michigan School of Medicine
Ende Zhao: University of Michigan School of Medicine
Linda Vatan: University of Michigan School of Medicine
Wojciech Szeliga: University of Michigan School of Medicine
Jan Kotarski: Medical University in Lublin
Rafał Tarkowski: Medical University in Lublin
Yali Dou: University of Michigan School of Medicine
Kathleen Cho: University of Michigan School of Medicine
Sharon Hensley-Alford: Henry Ford Health System
Adnan Munkarah: Henry Ford Health System
Rebecca Liu: The University of Michigan Comprehensive Cancer Center, University of Michigan
Weiping Zou: University of Michigan School of Medicine

Nature, 2015, vol. 527, issue 7577, 249-253

Abstract: Treating ovarian cancer in mouse models with inhibitors for the epigenetic regulators EZH2 and DNMT1 increases the expression of the inflammatory chemokines CXCL9 and CXCL10, resulting in enhanced tumour infiltration by effector T cells, and slowed tumour progression.

Date: 2015
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DOI: 10.1038/nature15520

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