Basomedial amygdala mediates top-down control of anxiety and fear

Avishek Adhikari, Talia N. Lerner, Joel Finkelstein, Sally Pak, Joshua H. Jennings, Thomas J. Davidson, Emily Ferenczi, Lisa A. Gunaydin, Julie J. Mirzabekov, Li Ye, Sung-Yon Kim, Anna Lei and Karl Deisseroth ()
Additional contact information
Avishek Adhikari: Stanford University
Talia N. Lerner: Stanford University
Joel Finkelstein: Stanford University
Sally Pak: Stanford University
Joshua H. Jennings: Stanford University
Thomas J. Davidson: Stanford University
Emily Ferenczi: Stanford University
Lisa A. Gunaydin: Stanford University
Julie J. Mirzabekov: Stanford University
Li Ye: Stanford University
Sung-Yon Kim: Stanford University
Anna Lei: Stanford University
Karl Deisseroth: Stanford University

Nature, 2015, vol. 527, issue 7577, 179-185

Abstract: Activation of the ventral medial prefrontal cortex–basomedial amygdala pathway is shown to suppress anxiety and fear-related freezing in mice, thus identifying the basomedial amygdala (and not intercalated cells, as posited by earlier models) as a novel target of top-down control.

Date: 2015
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DOI: 10.1038/nature15698

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