Histone H1 couples initiation and amplification of ubiquitin signalling after DNA damage

Tina Thorslund, Anita Ripplinger, Saskia Hoffmann, Thomas Wild, Michael Uckelmann, Bine Villumsen, Takeo Narita, Titia K. Sixma, Chunaram Choudhary, Simon Bekker-Jensen and Niels Mailand ()
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Tina Thorslund: Ubiquitin Signaling Group, Protein Signaling Program, The Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen
Anita Ripplinger: Ubiquitin Signaling Group, Protein Signaling Program, The Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen
Saskia Hoffmann: Ubiquitin Signaling Group, Protein Signaling Program, The Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen
Thomas Wild: Proteomics Program, The Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen
Michael Uckelmann: Cancer Genomics Center, Netherlands Cancer Institute
Bine Villumsen: Ubiquitin Signaling Group, Protein Signaling Program, The Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen
Takeo Narita: Proteomics Program, The Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen
Titia K. Sixma: Cancer Genomics Center, Netherlands Cancer Institute
Chunaram Choudhary: Proteomics Program, The Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen
Simon Bekker-Jensen: Ubiquitin Signaling Group, Protein Signaling Program, The Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen
Niels Mailand: Ubiquitin Signaling Group, Protein Signaling Program, The Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen

Nature, 2015, vol. 527, issue 7578, 389-393

Abstract: At the initiation of DNA double-strand break repair, a number of ubiquitylation events occur; here, the RNF8 ubiquitin E3 ligase and the ubiquitin-conjugating E2 enzyme, UBC13, are shown to primarily modify H1-type linker histones, via a K63 linkage.

Date: 2015
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DOI: 10.1038/nature15401

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