DNA-dependent formation of transcription factor pairs alters their binding specificity

Arttu Jolma, Yimeng Yin, Kazuhiro R. Nitta, Kashyap Dave, Alexander Popov, Minna Taipale, Martin Enge, Teemu Kivioja, Ekaterina Morgunova and Jussi Taipale ()
Additional contact information
Arttu Jolma: Karolinska Institutet
Yimeng Yin: Karolinska Institutet
Kazuhiro R. Nitta: Karolinska Institutet
Kashyap Dave: Karolinska Institutet
Alexander Popov: European Synchrotron Radiation Facility
Minna Taipale: Karolinska Institutet
Martin Enge: Karolinska Institutet
Teemu Kivioja: Genome-Scale Biology Program, University of Helsinki
Ekaterina Morgunova: Karolinska Institutet
Jussi Taipale: Karolinska Institutet

Nature, 2015, vol. 527, issue 7578, 384-388

Abstract: A high-throughput analysis of DNA binding in over 9,000 interacting transcription factor pairs reveals that the interactions are often actively mediated by the DNA itself and the composite DNA sites recognized are different from the individual motifs of each transcription factor.

Date: 2015
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DOI: 10.1038/nature15518

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