Diversion of aspartate in ASS1-deficient tumours fosters de novo pyrimidine synthesis

Shiran Rabinovich, Lital Adler, Keren Yizhak, Alona Sarver, Alon Silberman, Shani Agron, Noa Stettner, Qin Sun, Alexander Brandis, Daniel Helbling, Stanley Korman, Shalev Itzkovitz, David Dimmock, Igor Ulitsky, Sandesh C. S. Nagamani, Eytan Ruppin and Ayelet Erez ()
Additional contact information
Shiran Rabinovich: Weizmann Institute of Science
Lital Adler: Weizmann Institute of Science
Keren Yizhak: The Blavatnik School of Computer Science, Tel Aviv University
Alona Sarver: Weizmann Institute of Science
Alon Silberman: Weizmann Institute of Science
Shani Agron: Weizmann Institute of Science
Noa Stettner: Weizmann Institute of Science
Qin Sun: Baylor College of Medicine, Houston
Alexander Brandis: Biological Services, Weizmann Institute of Science
Daniel Helbling: Human and Molecular Genetic and Biochemistry Center, Medical College Wisconsin
Stanley Korman: Genetic and Metabolic Center, Hadassah Medical Center
Shalev Itzkovitz: Weizmann Institute of Science
David Dimmock: Human and Molecular Genetic and Biochemistry Center, Medical College Wisconsin
Igor Ulitsky: Weizmann Institute of Science
Sandesh C. S. Nagamani: Baylor College of Medicine, Houston
Eytan Ruppin: The Blavatnik School of Computer Science, Tel Aviv University
Ayelet Erez: Weizmann Institute of Science

Nature, 2015, vol. 527, issue 7578, 379-383

Abstract: ASS1, a urea cycle enzyme, promotes cancer cell proliferation by facilitating pyrimidine synthesis via CAD (carbamoyl-phosphate synthase 2, aspartate transcarbamylase, and dihydroorotase complex) activation.

Date: 2015
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DOI: 10.1038/nature15529

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