RETRACTED ARTICLE: Endoperoxide formation by an α-ketoglutarate-dependent mononuclear non-haem iron enzyme

Wupeng Yan, Heng Song, Fuhang Song, Yisong Guo, Cheng-Hsuan Wu, Ampon Sae Her, Yi Pu, Shu Wang, Nathchar Naowarojna, Andrew Weitz, Michael P. Hendrich, Catherine E. Costello, Lixin Zhang (), Pinghua Liu () and Yan Jessie Zhang ()
Additional contact information
Wupeng Yan: University of Texas at Austin
Heng Song: Boston University
Fuhang Song: CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences
Yisong Guo: Carnegie Mellon University
Cheng-Hsuan Wu: Boston University
Ampon Sae Her: Boston University
Yi Pu: Boston University
Shu Wang: Boston University
Nathchar Naowarojna: Boston University
Andrew Weitz: Carnegie Mellon University
Michael P. Hendrich: Carnegie Mellon University
Catherine E. Costello: Boston University
Lixin Zhang: CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences
Pinghua Liu: Boston University
Yan Jessie Zhang: University of Texas at Austin

Nature, 2015, vol. 527, issue 7579, 539-543

Abstract: The X-ray crystal structures of FtmOx1, the first known α-ketoglutarate-dependent mononuclear non-haem iron enzyme that can catalyse an endoperoxide formation reaction, are presented, along with further biochemical analyses which reveal the catalytic versatility of mononuclear non-haem iron enzymes, and help to unravel the mechanisms of endoperoxide biosyntheses.

Date: 2015
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DOI: 10.1038/nature15519

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