Epithelial-to-mesenchymal transition is dispensable for metastasis but induces chemoresistance in pancreatic cancer

Xiaofeng Zheng, Julienne L. Carstens, Jiha Kim, Matthew Scheible, Judith Kaye, Hikaru Sugimoto, Chia-Chin Wu, Valerie S. LeBleu and Raghu Kalluri ()
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Xiaofeng Zheng: Metastasis Research Center, University of Texas MD Anderson Cancer Center
Julienne L. Carstens: Metastasis Research Center, University of Texas MD Anderson Cancer Center
Jiha Kim: Metastasis Research Center, University of Texas MD Anderson Cancer Center
Matthew Scheible: Metastasis Research Center, University of Texas MD Anderson Cancer Center
Judith Kaye: Metastasis Research Center, University of Texas MD Anderson Cancer Center
Hikaru Sugimoto: Metastasis Research Center, University of Texas MD Anderson Cancer Center
Chia-Chin Wu: University of Texas MD Anderson Cancer Center
Valerie S. LeBleu: Metastasis Research Center, University of Texas MD Anderson Cancer Center
Raghu Kalluri: Metastasis Research Center, University of Texas MD Anderson Cancer Center

Nature, 2015, vol. 527, issue 7579, 525-530

Abstract: Deletion of Twist or Snail, two key transcription factors that induce epithelial-to-mesenchymal transition in a mouse model of pancreatic ductal adenocarcinoma leads to an increase in cell proliferation, and a greater sensitivity to the chemotherapeutic agent gemcitabine, with no effect on invasion or metastasis.

Date: 2015
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DOI: 10.1038/nature16064

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