Transcriptional regulators form diverse groups with context-dependent regulatory functions

Gerald Stampfel, Tomáš Kazmar, Olga Frank, Sebastian Wienerroither, Franziska Reiter and Alexander Stark ()
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Gerald Stampfel: Research Institute of Molecular Pathology (IMP), Vienna Biocenter (VBC)
Tomáš Kazmar: Research Institute of Molecular Pathology (IMP), Vienna Biocenter (VBC)
Olga Frank: Research Institute of Molecular Pathology (IMP), Vienna Biocenter (VBC)
Sebastian Wienerroither: Research Institute of Molecular Pathology (IMP), Vienna Biocenter (VBC)
Franziska Reiter: Research Institute of Molecular Pathology (IMP), Vienna Biocenter (VBC)
Alexander Stark: Research Institute of Molecular Pathology (IMP), Vienna Biocenter (VBC)

Nature, 2015, vol. 528, issue 7580, 147-151

Abstract: A large-scale enhancer complementation assay assessing the activating or repressing contributions of over 800 Drosophila transcription factors and cofactors to combinatorial enhancer control reveals a more complex picture than expected, with many factors having diverse regulatory functions that depend on the enhancer context.

Date: 2015
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DOI: 10.1038/nature15545

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