Therapeutic antibodies reveal Notch control of transdifferentiation in the adult lung

Daniel Lafkas, Amy Shelton, Cecilia Chiu, Gladys de Leon Boenig, Yongmei Chen, Scott S. Stawicki, Christian Siltanen, Mike Reichelt, Meijuan Zhou, Xiumin Wu, Jeffrey Eastham-Anderson, Heather Moore, Meron Roose-Girma, Yvonne Chinn, Julie Q. Hang, Søren Warming, Jackson Egen, Wyne P. Lee, Cary Austin, Yan Wu, Jian Payandeh, John B. Lowe and Christian W. Siebel ()
Additional contact information
Daniel Lafkas: Genentech, Inc.
Amy Shelton: Genentech, Inc.
Cecilia Chiu: Genentech, Inc.
Gladys de Leon Boenig: Genentech, Inc.
Yongmei Chen: Genentech, Inc.
Scott S. Stawicki: Genentech, Inc.
Christian Siltanen: Genentech, Inc.
Mike Reichelt: Genentech, Inc.
Meijuan Zhou: Genentech, Inc.
Xiumin Wu: Genentech, Inc.
Jeffrey Eastham-Anderson: Genentech, Inc.
Heather Moore: Genentech, Inc.
Meron Roose-Girma: Genentech, Inc.
Yvonne Chinn: Genentech, Inc.
Julie Q. Hang: Genentech, Inc.
Søren Warming: Genentech, Inc.
Jackson Egen: Genentech, Inc.
Wyne P. Lee: Genentech, Inc.
Cary Austin: Genentech, Inc.
Yan Wu: Genentech, Inc.
Jian Payandeh: Genentech, Inc.
John B. Lowe: Genentech, Inc.
Christian W. Siebel: Genentech, Inc.

Nature, 2015, vol. 528, issue 7580, 127-131

Abstract: Inhibitory antibodies to two specific human and mouse Notch ligands, Jagged1 and Jagged2, are generated and shown to have beneficial effects in a goblet cell metaplasia asthma model; systemic Jagged1 inhibition transdifferentiates secretory cells into ciliated cells in the mouse, demonstrating that Jagged1 from ciliated cells normally holds back secretory cells to adopt the ciliated fate.

Date: 2015
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DOI: 10.1038/nature15715

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