Genome-wide detection of DNase I hypersensitive sites in single cells and FFPE tissue samples

Wenfei Jin, Qingsong Tang, Mimi Wan, Kairong Cui, Yi Zhang, Gang Ren, Bing Ni, Jeffrey Sklar, Teresa M. Przytycka, Richard Childs, David Levens and Keji Zhao ()
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Wenfei Jin: Systems Biology Center, National Heart, Lung, and Blood Institute, National Institutes of Health
Qingsong Tang: Systems Biology Center, National Heart, Lung, and Blood Institute, National Institutes of Health
Mimi Wan: Yale University School of Medicine
Kairong Cui: Systems Biology Center, National Heart, Lung, and Blood Institute, National Institutes of Health
Yi Zhang: Systems Biology Center, National Heart, Lung, and Blood Institute, National Institutes of Health
Gang Ren: Systems Biology Center, National Heart, Lung, and Blood Institute, National Institutes of Health
Bing Ni: Institute of Immunology, Third Military Medical University of the People’s Liberation Army
Jeffrey Sklar: Yale University School of Medicine
Teresa M. Przytycka: Computational Biology Branch, National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health
Richard Childs: Hematology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health
David Levens: Laboratory of Pathology, National Cancer Institute, National Institutes of Health
Keji Zhao: Systems Biology Center, National Heart, Lung, and Blood Institute, National Institutes of Health

Nature, 2015, vol. 528, issue 7580, 142-146

Abstract: A DNase sequencing method termed scDNase-seq detects DNase I hypersensitive sites genome-wide in single cells and pools of cells dissected from cancer biopsies.

Date: 2015
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DOI: 10.1038/nature15740

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