A mechanism for expansion of regulatory T-cell repertoire and its role in self-tolerance

Yongqiang Feng, Joris van der Veeken, Mikhail Shugay, Ekaterina V. Putintseva, Hatice U. Osmanbeyoglu, Stanislav Dikiy, Beatrice E. Hoyos, Bruno Moltedo, Saskia Hemmers, Piper Treuting, Christina S. Leslie, Dmitriy M. Chudakov and Alexander Y. Rudensky ()
Additional contact information
Yongqiang Feng: Howard Hughes Medical Institute and Immunology Program, Ludwig Center at Memorial Sloan Kettering Cancer Center, Memorial Sloan Kettering Cancer Center
Joris van der Veeken: Howard Hughes Medical Institute and Immunology Program, Ludwig Center at Memorial Sloan Kettering Cancer Center, Memorial Sloan Kettering Cancer Center
Mikhail Shugay: Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry RAS
Ekaterina V. Putintseva: Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry RAS
Hatice U. Osmanbeyoglu: Computational Biology Program, Memorial Sloan Kettering Cancer Center
Stanislav Dikiy: Howard Hughes Medical Institute and Immunology Program, Ludwig Center at Memorial Sloan Kettering Cancer Center, Memorial Sloan Kettering Cancer Center
Beatrice E. Hoyos: Howard Hughes Medical Institute and Immunology Program, Ludwig Center at Memorial Sloan Kettering Cancer Center, Memorial Sloan Kettering Cancer Center
Bruno Moltedo: Howard Hughes Medical Institute and Immunology Program, Ludwig Center at Memorial Sloan Kettering Cancer Center, Memorial Sloan Kettering Cancer Center
Saskia Hemmers: Howard Hughes Medical Institute and Immunology Program, Ludwig Center at Memorial Sloan Kettering Cancer Center, Memorial Sloan Kettering Cancer Center
Piper Treuting: School of Medicine, University of Washington
Christina S. Leslie: Computational Biology Program, Memorial Sloan Kettering Cancer Center
Dmitriy M. Chudakov: Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry RAS
Alexander Y. Rudensky: Howard Hughes Medical Institute and Immunology Program, Ludwig Center at Memorial Sloan Kettering Cancer Center, Memorial Sloan Kettering Cancer Center

Nature, 2015, vol. 528, issue 7580, 132-136

Abstract: Regulatory T cells need to express a diverse T-cell-receptor repertoire to control pathogenic self-reactive T cells; here it is shown that repertoire diversification depends on the intronic Foxp3 enhancer CNS3 acting at the regulatory T-cell-precursor stage to induce T-cell-receptor responsiveness to low-strength signals.

Date: 2015
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DOI: 10.1038/nature16141

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