Force generation by skeletal muscle is controlled by mechanosensing in myosin filaments

Marco Linari, Elisabetta Brunello, Massimo Reconditi, Luca Fusi, Marco Caremani, Theyencheri Narayanan, Gabriella Piazzesi, Vincenzo Lombardi () and Malcolm Irving
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Marco Linari: Laboratory of Physiology, Università di Firenze
Elisabetta Brunello: Laboratory of Physiology, Università di Firenze
Massimo Reconditi: Laboratory of Physiology, Università di Firenze
Luca Fusi: King’s College London
Marco Caremani: Laboratory of Physiology, Università di Firenze
Theyencheri Narayanan: European Synchrotron Radiation Facility
Gabriella Piazzesi: Laboratory of Physiology, Università di Firenze
Vincenzo Lombardi: Laboratory of Physiology, Università di Firenze
Malcolm Irving: King’s College London

Nature, 2015, vol. 528, issue 7581, 276-279

Abstract: It is widely accepted that contraction of skeletal muscle and the heart involves structural changes in actin-containing thin filaments to allow binding of myosin motors from neighbouring thick filaments, thus driving filament sliding; here, X-ray diffraction of single skeletal muscle cells reveals that this thin-filament mechanism can regulate muscle contraction against low load, but high-load contraction requires a second permissive step involving a structural change in the thick filament.

Date: 2015
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DOI: 10.1038/nature15727

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