Barcoding reveals complex clonal dynamics of de novo transformed human mammary cells

Long V. Nguyen, Davide Pellacani, Sylvain Lefort, Nagarajan Kannan, Tomo Osako, Maisam Makarem, Claire L. Cox, William Kennedy, Philip Beer, Annaick Carles, Michelle Moksa, Misha Bilenky, Sneha Balani, Sonja Babovic, Ivan Sun, Miriam Rosin, Samuel Aparicio, Martin Hirst and Connie J. Eaves ()
Additional contact information
Long V. Nguyen: Terry Fox Laboratory, BC Cancer Agency
Davide Pellacani: Terry Fox Laboratory, BC Cancer Agency
Sylvain Lefort: Terry Fox Laboratory, BC Cancer Agency
Nagarajan Kannan: Terry Fox Laboratory, BC Cancer Agency
Tomo Osako: University of British Columbia
Maisam Makarem: Terry Fox Laboratory, BC Cancer Agency
Claire L. Cox: Terry Fox Laboratory, BC Cancer Agency
William Kennedy: Terry Fox Laboratory, BC Cancer Agency
Philip Beer: Terry Fox Laboratory, BC Cancer Agency
Annaick Carles: Centre for High-Throughput Biology, University of British Columbia
Michelle Moksa: Centre for High-Throughput Biology, University of British Columbia
Misha Bilenky: Centre for High-Throughput Biology, University of British Columbia
Sneha Balani: Terry Fox Laboratory, BC Cancer Agency
Sonja Babovic: Terry Fox Laboratory, BC Cancer Agency
Ivan Sun: Biomedical Physiology and Kinesiology, Simon Fraser University, 8888 University Drive
Miriam Rosin: Biomedical Physiology and Kinesiology, Simon Fraser University, 8888 University Drive
Samuel Aparicio: University of British Columbia
Martin Hirst: Centre for High-Throughput Biology, University of British Columbia
Connie J. Eaves: Terry Fox Laboratory, BC Cancer Agency

Nature, 2015, vol. 528, issue 7581, 267-271

Abstract: The first formal evidence of the shared and independent ability of basal cells and luminal pro-genitors isolated from normal human mammary tissue and transduced with a single oncogene to initiate tumorigeneses when introduced into mice.

Date: 2015
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DOI: 10.1038/nature15742

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