Disentangling type 2 diabetes and metformin treatment signatures in the human gut microbiota

Kristoffer Forslund, Falk Hildebrand, Trine Nielsen, Gwen Falony, Emmanuelle Le Chatelier, Shinichi Sunagawa, Edi Prifti, Sara Vieira-Silva, Valborg Gudmundsdottir, Helle Krogh Pedersen, Manimozhiyan Arumugam, Karsten Kristiansen, Anita Yvonne Voigt, Henrik Vestergaard, Rajna Hercog, Paul Igor Costea, Jens Roat Kultima, Junhua Li, Torben Jørgensen, Florence Levenez, Joël Dore, H. Bjørn Nielsen, Søren Brunak, Jeroen Raes, Torben Hansen, Jun Wang, S. Dusko Ehrlich (), Peer Bork () and Oluf Pedersen ()
Additional contact information
Kristoffer Forslund: European Molecular Biology Laboratory, Structural and Computational Biology Unit
Falk Hildebrand: European Molecular Biology Laboratory, Structural and Computational Biology Unit
Trine Nielsen: The Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen
Gwen Falony: VIB Center for the Biology of Disease, Katholieke Universiteit Leuven
Emmanuelle Le Chatelier: MICALIS, Institut National de la Recherche Agronomique
Shinichi Sunagawa: European Molecular Biology Laboratory, Structural and Computational Biology Unit
Edi Prifti: MICALIS, Institut National de la Recherche Agronomique
Sara Vieira-Silva: VIB Center for the Biology of Disease, Katholieke Universiteit Leuven
Valborg Gudmundsdottir: Center for Biological Sequence Analysis, Technical University of Denmark
Helle Krogh Pedersen: Center for Biological Sequence Analysis, Technical University of Denmark
Manimozhiyan Arumugam: The Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen
Karsten Kristiansen: University of Copenhagen
Anita Yvonne Voigt: European Molecular Biology Laboratory, Structural and Computational Biology Unit
Henrik Vestergaard: The Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen
Rajna Hercog: European Molecular Biology Laboratory, Structural and Computational Biology Unit
Paul Igor Costea: European Molecular Biology Laboratory, Structural and Computational Biology Unit
Jens Roat Kultima: European Molecular Biology Laboratory, Structural and Computational Biology Unit
Junhua Li: Bejing Genomics Institute (BGI)-Shenzhen
Torben Jørgensen: Research Centre for Prevention and Health
Florence Levenez: MICALIS, Institut National de la Recherche Agronomique
Joël Dore: MICALIS, Institut National de la Recherche Agronomique
H. Bjørn Nielsen: Center for Biological Sequence Analysis, Technical University of Denmark
Søren Brunak: Center for Biological Sequence Analysis, Technical University of Denmark
Jeroen Raes: VIB Center for the Biology of Disease, Katholieke Universiteit Leuven
Torben Hansen: The Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen
Jun Wang: University of Copenhagen
S. Dusko Ehrlich: MICALIS, Institut National de la Recherche Agronomique
Peer Bork: European Molecular Biology Laboratory, Structural and Computational Biology Unit
Oluf Pedersen: The Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen

Nature, 2015, vol. 528, issue 7581, 262-266

Abstract: Growing evidence from metagenome-wide association studies link multiple common disorders to microbial dysbiosis but effects of drug treatment are often not accounted for; here, the authors re-analyse two previous metagenomic studies of type 2 diabetes mellitus patients together with a novel cohort to determine the effects of the widely prescribed antidiabetic drug metformin and highlight the need to distinguish the effects of a disease from the effects of treatment on the gut microbiota.

Date: 2015
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DOI: 10.1038/nature15766

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