Molecular structures of unbound and transcribing RNA polymerase III

Niklas A. Hoffmann, Arjen J. Jakobi, María Moreno-Morcillo, Sebastian Glatt, Jan Kosinski, Wim J. H. Hagen, Carsten Sachse () and Christoph W. Müller ()
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Niklas A. Hoffmann: European Molecular Biology Laboratory (EMBL), Structural and Computational Biology Unit
Arjen J. Jakobi: European Molecular Biology Laboratory (EMBL), Structural and Computational Biology Unit
María Moreno-Morcillo: European Molecular Biology Laboratory (EMBL), Structural and Computational Biology Unit
Sebastian Glatt: European Molecular Biology Laboratory (EMBL), Structural and Computational Biology Unit
Jan Kosinski: European Molecular Biology Laboratory (EMBL), Structural and Computational Biology Unit
Wim J. H. Hagen: European Molecular Biology Laboratory (EMBL), Structural and Computational Biology Unit
Carsten Sachse: European Molecular Biology Laboratory (EMBL), Structural and Computational Biology Unit
Christoph W. Müller: European Molecular Biology Laboratory (EMBL), Structural and Computational Biology Unit

Nature, 2015, vol. 528, issue 7581, 231-236

Abstract: RNA polymerase III (Pol III), the largest eukaryote polymerase yet characterized, transcribes structured small non-coding RNAs; here cryo-electron microscopy structures of budding yeast Pol III allow building of an atomic-level model of the complete 17-subunit complex, both unbound and while elongating RNA.

Date: 2015
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DOI: 10.1038/nature16143

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