Neutrophils support lung colonization of metastasis-initiating breast cancer cells

Stefanie K. Wculek and Ilaria Malanchi ()
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Stefanie K. Wculek: The Francis Crick Institute, Lincolns Inn Fields Laboratories
Ilaria Malanchi: The Francis Crick Institute, Lincolns Inn Fields Laboratories

Nature, 2015, vol. 528, issue 7582, 413-417

Abstract: Neutrophils are shown to have a role in driving the metastasis of breast cancer cells to the lung, with neutrophil-derived leukotrienes promoting metastatic initiation in the lung by expanding the sub-pool of cancer cells with high tumorigenic potential.

Date: 2015
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DOI: 10.1038/nature16140

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